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The oral Janus kinase (JAK) inhibitor baricitinib has demonstrated efficacy for severe alopecia areata (AA) over 36 weeks. There are limited data on the longer-term treatment of AA.The aim of this study was to evaluate the efficacy and safety of baricitinib ...
Mar 26, 2022 · Baricitinib Demonstrates Rapid Action Within Just 2 Months of Treatment in Severe and Unresponsive Alopecia Areata: A Case Report, Dermatology The American Medical Journal, (2024). https://doi.org ...
Jan 30, 2024 · OLUMIANT is taken once daily, as a systemic treatment for adults with severe alopecia areata (AA), as 2 mg or 4 mg tablets orally.1The recommended dose of OLUMIANT for patients living with severe alopecia areata is 2 mg/day, with an increase to 4 mg/day if treatment response is not adequate. For patients with nearly complete or complete scalp ...
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Among patients randomized at baseline to baricitinib 4 mg and 2 mg, respectively, 252/281 (89.7%) and 163/184 (88.6%) in BRAVE-AA1 and 209/234 (89.3%) and 134/156 (85.9%) in BRAVE-AA2 completed 52 weeks of study treatment (ESM Fig. S1). The most common reasons for discontinuation in BRAVE-AA1 and BRAVE-AA2 were patient withdrawal (n = 21 and n = 21...
The proportions of patients achieving SALT score ≤ 20 continuously increased over the treatment period, with response rates for patients treated with baricitinib 4 mg and 2 mg, respectively, reaching 40.9% and 21.2% in BRAVE-AA1 and 36.8% and 24.4% in BRAVE-AA2 at Week 52 (Fig. 1, ESM Table S1). Among patients with severe baseline disease (SALT sco...
A total of 280 (patient-years exposure [PYE] = 385.5) and 183 (PYE = 197.9) patients in BRAVE-AA1 and 233 (PYE = 284.8) and 155 (PYE = 168.7) patients in BRAVE-AA2 were exposed to baricitinib 4 mg and 2 mg, respectively. Among patients in the baricitinib 4 mg and 2 mg groups, respectively, treatment-emergent AEs (TEAEs) were reported in 69.6% (IR =...
- Ohsang Kwon
Jan 19, 2024 · Alopecia areata (AA), characterized by immune-mediated hair loss without scarring, leads to substantial emotional distress because of high relapse rates despite conventional treatment in severe cases.1 Janus kinase (JAK) inhibitors target the JAK-STAT signaling pathway, reducing hair follicle inflammation.2 Baricitinib, an oral JAK1/JAK2 inhibitor, has been approved for AA treatment, but ...
Jun 16, 2023 · Baricitinib (Olumiant®), a Janus kinase (JAK) inhibitor, is the first drug approved for the treatment of severe alopecia areata in the USA and the EU. Severe alopecia areata is usually difficult to treat and relapse is common. Patients with this disorder are more likely to suffer from anxiety and depression. In two pivotal placebo-controlled phase 3 clinical trials in adults with severe ...
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Apr 12, 2023 · One such drug, baricitinib, has recently demonstrated significant hair regrowth in phase 2 and 3 alopecia areata trials. It has since become the first systemic therapy approved for treating severe alopecia areata. This review examines the role of Janus kinase pathways in alopecia areata's pathogenesis and the safety and efficacy of baricitinib ...
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