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Dec 13, 2022 · The exact role of glutamine in cancer is still being understood. Research has found that certain types of cancer cells may need it to grow and spread, as well as to regulate various activities ...
Apr 24, 2019 · Summary. Like all cells, cancer cells need nutrients to grow. Sugar is one important fuel, but it’s far from cancer’s only requirement. Current research is aimed at targeting cancer’s dependence on the amino acid glutamine as a weakness. In 1955, an American doctor named Harry Eagle made a surprising discovery about cancer cells growing ...
Nov 8, 2019 · In theory, this compound could be used across a wide spectrum of cancer types, says Jonathan Powell, M.D., Ph.D., associate director of the Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center, and colleagues due to the critical role of glutamine in promoting the metabolism necessary for prodigious tumor growth.
Apr 3, 2023 · In addition, given that immune checkpoint inhibitors are now widely used to treat cancer, the role of glutamine blockade within the tumor microenvironment (TME) has gained much attention 7.
Glutamine metabolism is one of the metabolic pathways that can be successfully targeted in cancer treatment. The dependence of many hematological and solid tumors on glutamine is associated with mitochondrial glutaminase (GLS) activity that enables channeling of glutamine into the tricarboxylic acid (TCA) cycle, generation of ATP and NADPH, and regulation of glutathione homeostasis and ...
These observations mirror the dependence of growing cancer cells on glutamine 5, with some cancer cells dying rapidly if glutamine is deprived 6. Circulating glutamine is the most abundant amino acid (~500 μM) 7, making up over 20% of the free amino acid pool in blood and 40% in muscle 8. While diet can serve as a source of glutamine from ...
To date, many studies have explored the role of glutamine metabolism in cancer, thereby providing a scientific rationale for targeting glutamine metabolism for cancer treatment. In this review, we summarize the mechanism(s) involved at each step of glutamine metabolism, from glutamine transporters to redox homeostasis, and highlight areas that can be exploited for clinical cancer treatment.
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