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Nov 22, 2019 · Cancer cells in a growing tumor can adapt to oxygen deprivation by hijacking these HIFs. The HIFs can initiate the formation of new blood vessels to improve oxygen delivery. In addition, the HIFs change how cancer cells metabolize glucose (sugar) so that it can still be used to make energy even in the absence of oxygen.
- William G. Kaelin Jr., MD
The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing...
- Research
Bispecific antibody therapies are a type of immunotherapy...
- Dana-Farber Staff
Uterine cancer — also known as endometrial cancer — has...
- William G. Kaelin Jr., MD
Jul 10, 2023 · Oxygen in tumors is necessary for radiotherapy to effectively treat cancer, but when tumors are hypoxic, this method can fail. A new strategy for raising tumor oxygen levels entails injecting oxygen-filled bubbles into the body and using ultrasound to burst them just at the tumor site.
Nov 7, 2019 · Using cells from human breast cancers and mouse breast cancer models, researchers at the Johns Hopkins Kimmel Cancer Center say they have significant new evidence that tumor cells exposed to low-oxygen conditions have an advantage when it comes to invading and surviving in the bloodstream.
Primary antitumor effect of hyperoxic therapy may be due to the reversal of tumor hypoxia and the generation of reactive oxygen species. Restoring immune function is also suggested as a potential mechanism. Hyperoxic therapy can also cause cellular injury and organ dysfunction.
Mar 14, 2024 · Researchers at the Francis Crick Institute have shed light on how cancer cells survive in the first few hours after being cut off from a supply of oxygen. Published today in The EMBO Journal, this finding could one day help to prevent cancer from becoming resistant to therapy.
Support for the hypothesis that oxygen-deficient cells in patient tumors could affect the ability to control malignant disease at the local treatment site comes from three types of radiotherapy investigations; (i) studies of physiological variables associated with hypoxia, (ii) the direct assessments of oxygenation in situ, and (iii) outcomes ...
Jun 8, 2021 · HBOT increasing in oxygen partial pressure may benefit tumor suppression. In this study, we investigated the effects of HBOT on solid tumors, such as lung cancer.
