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Apr 24, 2019 · Summary. Like all cells, cancer cells need nutrients to grow. Sugar is one important fuel, but it’s far from cancer’s only requirement. Current research is aimed at targeting cancer’s dependence on the amino acid glutamine as a weakness. In 1955, an American doctor named Harry Eagle made a surprising discovery about cancer cells growing ...
- Natasha Pavlova
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- Brain Tumors & Brain Cancer
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- Natasha Pavlova
Mar 8, 2024 · Glutamine metabolism plays a pivotal role in cancer progression, immune cell function, and the modulation of the tumor microenvironment. Dysregulated glutamine metabolism has been implicated in cancer development and immune responses, supported by mounting evidence. Cancer cells heavily rely on glutamine as a critical nutrient for survival and proliferation, while immune cells require ...
Apr 3, 2023 · PET tracers showed that cancer cells rely heavily on glutamine uptake via mTORC1 signaling, while myeloid cells in the TME are more dependent on glucose, as are T cells and cancer cells (but to a ...
May 21, 2021 · Through 13 C 5-glutamine labeling experiments, they found that these prostate cancer cells also exhibited a greater reliance on glutamine following exosome uptake, with increased levels of 1 3 C-labeled m + 5 α-KG and m + 5 glutamate indicative of reductive glutamine metabolism for anaplerosis into the TCA cycle. This data suggests that CAFs are capable of shifting the metabolism of cancer ...
- Ting Li, Christopher Copeland, Anne Le
- 2021/05/21
- 10.1007/978-3-030-65768-0_2
Feb 15, 2017 · The synthesis or uptake, and the utilization, of glutamine in cancer cells is highly flexible and is dependent on cell origin, oncogenic drivers, and the tumor microenvironment. Some tumor types rely on catabolism of exogenous glutamine, and might be effectively targeted by therapeutic regimes involving glutaminase inhibition.
- Ahmad A. Cluntun, Michael J. Lukey, Richard A. Cerione, Jason W. Locasale
- 2017
Jul 29, 2016 · Key Points. Cancer cells show increased consumption of and dependence on glutamine. Glutamine metabolism fuels the tricarboxylic acid (TCA) cycle, nucleotide and fatty acid biosynthesis, and redox ...
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Sep 17, 2020 · SLC1A5 might not be an appropriate target for suppressing glutamine uptake by cancer cells because it is not the only plasma membrane glutamine transporter, and its function would therefore be ...
