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      • Although for decades cancer has been viewed as a process governed by genetic mechanisms, it is becoming more and more clear that non-genetic mechanisms may play an equally important role in cancer evolution.
      www.ncbi.nlm.nih.gov/pmc/articles/PMC8002988/

      Genetic and Non-Genetic Mechanisms Underlying Cancer Evolution

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  3. www.ncbi.nlm.nih.gov › pmc › articlesGenetic and Non-Genetic Mechanisms Underlying Cancer Evolution

    Mar 18, 2021 · Non-genetic mechanisms (histones and DNA modifications, imprinting, paramutation, posttranslational gene silencing, etc.) can lead to the establishment of metastable and stable phenotypic states that can be inherited upon cell division and propagated through many cell generations.

  4. www.ncbi.nlm.nih.gov › pmc › articlesDecoding Cancer Evolution: Integrating Genetic and Non ...

    Sep 24, 2023 · In this review, we delve into the dynamics of the shift from multicellularity to unicellularity during cancer onset and progression. We highlight the role of genetic and non-genetic factors, as well as tumour microenvironment, in promoting ITH and cancer evolution.

    • 10.3390/genes14101856
    • 2023/10
    • Genes (Basel). 2023 Oct; 14(10): 1856.

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  6. www.nature.com › articles › s41568/020/00302-4Non-genetic mechanisms of therapeutic resistance in cancer

    Oct 8, 2020 · This Perspective discusses how therapeutic resistance is not only driven by genetic evolution but often involves non-genetic adaptive mechanisms that are intimately linked.

    • Jean-Christophe Marine, Sarah-Jane Dawson, Sarah-Jane Dawson, Mark A Dawson, Mark A Dawson
    • 2020

  7. www.nature.com › articles › s41568/024/00734-2The evolutionary theory of cancer: challenges and potential ...

    Sep 10, 2024 · They also outline how other challenges, including non-genetic heredity, phenotypic plasticity, reticulate evolution and clone diversity, can be included in an expanded cancer evolutionary...

  8. pubmed.ncbi.nlm.nih.gov › 33803675Genetic and Non-Genetic Mechanisms Underlying Cancer Evolution

    Mar 18, 2021 · Herein, we discuss an up-to-date view of the fundamental genetic and non-genetic mechanisms underlying tumour evolution with the aim of concurring into an integrated view of the evolutionary forces at play throughout the emergence and progression of the disease and into the acquisition of resistance to diverse therapeutic paradigms.

    • Yelyzaveta Shlyakhtina, Katherine L. Moran, Maximiliano M. Portal
    • 2021

  9. www.ncbi.nlm.nih.gov › pmc › articlesPrinciples and mechanisms of non-genetic resistance in cancer

    Feb 2, 2020 · As well as undergoing genetic evolution, cancer cells can alter their epigenetic state to adapt and resist treatment. This non-genetic evolution is emerging as a major component of cancer resistance.

  10. pubmed.ncbi.nlm.nih.gov › 32807900Integrating genetic and non-genetic determinants of cancer ...

    In this Review, we discuss emerging analytic and experimental technologies for single-cell multi-omics that enable the capture and integration of multiple data modalities to inform the study of cancer evolution.

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