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      • Advances in clinical research and diagnostic testing methods over the last 3 decades suggest that an update for existing definitions and approaches for fever and inflammation of unknown origin is needed [1–4]. Classic fever of unknown origin (FUO) was first robustly studied in 1961, with subsequent modifications in definitions (Table 1) [1, 2].
      academic.oup.com/ofid/article/11/7/ofae298/7689389
  1. Feb 2, 2022 · In 1961, Petersdorf and Beeson defined fever of unknown origin (FUO) as a temperature of 38.3°C or higher for at least 3 weeks without a diagnosis, despite 1 week of inpatient...

  2. The majority of patients with unexplained FUO will eventually show spontaneous remission of fever. We describe the definition, diagnostic workup, causes and treatment of FUO. KEYWORDS : Fever of unknown origin, diagnosis, FDG-PET, infection, malignancy, connective tissue disease, systemic autoinflammatory diseases, treatment. Key points

  3. Petersdorf and Beeson [1] made it possible to perform epidemiological studies by introducing a definition of FUO, namely, an illness characterized by a rectal temperature of 38.3°C or higher on at least three occasions, evolving during at least 3 weeks, with no diagnosis reached after 1 week of ‘intelligent’ inpatient examination.

  4. Fever of unknown origin is defined as a clinically documented temperature of 101°F or higher on several occasions, coupled with an unrevealing diagnostic workup. The differential diagnosis is...

  5. Aug 14, 2023 · Fever of unknown origin (FUO) was first described by Dr. Petersdorf and Dr. Beesom in 1961. FUO was defined as a temperature of 101 degrees Fahrenheit (38.3 degrees Centigrade) or higher with a minimum duration of three weeks without an established diagnosis despite at least one week's investigation in the hospital.

    • Ilona Brown, Nancy A. Finnigan
    • 2023/08/14
    • 2021
  6. Nov 28, 2023 · Clinicians commonly refer to a febrile illness without an initially obvious etiology as fever of unknown origin (FUO). However, most febrile illnesses either resolve before a diagnosis can be made or develop distinguishing characteristics that lead to a diagnosis.

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  8. Aug 23, 2021 · This article presents a new fever of unknown origin definition that poses a reasonable starting point for building a consensus (Delphi) definition and creating an expert committee panel to steer research and clinical management into the future.

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