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- The structures illuminate an important role played by a stretch of 17 residues in the N-terminal region of EZH2, we call the activation loop, in the stimulation of the enzyme activity, inhibitor recognition and the potential development of the mutation-mediated drug resistance.
www.nature.com/articles/ncomms11384
People also ask
What is Polycomb Repressive Complex 2?
How does Polycomb Repressive Complex 2 mediate gene silencing?
Why are Polycomb Repressive Complex 1 and PRC2 important?
Does Polycomb Repressive Complex 2 methylate lysine 27?
Sep 7, 2018 · Polycomb repressive complex 2 (PRC2) methylates lysine 27 in histone H3, a modification associated with epigenetic gene silencing. This complex plays a fundamental role in regulating cellular differentiation and development, and PRC2 overexpression and mutations have been implicated in numerous cancers.
- Lindsay E. Moritz, Raymond C. Trievel
- 10.1074/jbc.R117.800367
- 2017
- 2018/09/09
Apr 28, 2016 · Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27).
- Alexei Brooun, Ketan S. Gajiwala, Ya-Li Deng, Wei Liu, Ben Bolaños, Patrick Bingham, You-Ai He, Wade...
- 2016
Aug 16, 2021 · Brooun, A. et al. Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance. Nat. Commun. 7, 11384 (2016).
- Neil P. Blackledge, Robert J. Klose
- 2021
May 16, 2019 · In this review, we discuss molecular mechanisms of the Polycomb group of proteins and its enzymatic role in epigenetics. More specifically, we focus on the Polycomb repressive complex 2 (PRC2) and the effects of its repressive marker. We have compiled information regarding the biological structure and how that impacts the stability of the complex.
- Valentina L Kouznetsova, Valentina L Kouznetsova, Alex Tchekanov, Xiaoming Li, Xiaowen Yan, Igor F T...
- 2019
Apr 28, 2016 · The structures illuminate an important role played by a stretch of 17 residues in the N-terminal region of EZH2, we call the activation loop, in the stimulation of the enzyme activity, inhibitor recognition and the potential development of the mutation-mediated drug resistance.
- Alexei Brooun, Ketan S. Gajiwala, Ya-Li Deng, Wei Liu, Ben Bolaños, Patrick Bingham, You-Ai He, Wade...
- 2016
Polycomb Repressive Complex 2. Numerous molecular processes conduct epigenetic regulation of protein transcription to maintain cell specification. In this review, we discuss molecular mechanisms of the Polycomb group of proteins and its enzymatic role in epigenetics.
Dec 1, 2020 · Structural biology research over the past decade has shed light on the molecular mechanisms of the assembly, catalysis, allosteric activation, autoinhibition, chemical inhibition, dimerization and chromatin targeting of various developmentally regulated PRC2 complexes.
