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As outlined here, inflammation can cause damage to the brain, especially in the hippocampus. However, inflammation caused by consumption of a high fat diet has not yet been well studied. A few recent studies from our laboratory and others have begun to investigate the role of a high fat diet on neuroinflammation and cognitive decline.
- Effect of High-Fat Diets on Oxidative Stress, Cellular ...
In a study by Woodie and Blythe focusing on hypercaloric...
- Inflammatory Links Between High Fat Diets and Diseases
High-fat diets (HFDs) induce metabolic inflammation...
- The Role of Hypothalamic Inflammation in Diet-Induced Obesity ...
Studies in rodents have shown that markers of inflammation...
- Effect of High-Fat Diets on Oxidative Stress, Cellular ...
In a study by Woodie and Blythe focusing on hypercaloric diet (high in fat and fructose) and its effects on cognitive health, the rats fed with a HFD exhibited a relatively high fat pad weight compared to the high-fructose group. This study further demonstrated that high-fructose diet promotes insulin dysregulation, development of hyperlipidemia, and impairs cognitive performance.
High-fat diets (HFDs) induce metabolic inflammation throughout the organism. The levels of endotoxins (e.g., LPS), circulating free fatty acids, and inflammatory mediators are increased in response to HFDs, resulting in low-grade systemic inflammation and altered homeostasis in many organs (see text).
Dec 6, 2017 · There is growing evidence that high-fat diets may compromise the hippocampus by sensitizing the immune cells (most likely microglia) of this brain structure, thus priming the inflammatory response ...
- Sarah J. Spencer, Aniko Korosi, Sophie Layé, Barbara Shukitt-Hale, Ruth M. Barrientos
- 2017
Jul 12, 2024 · Mechanisms include the effect of a high-fat diet on BBB permeability and inflammatory signalling in diverse cell types, disrupting central energy balance control and brain functions.
Feb 3, 2021 · Studies in rodents have shown that markers of inflammation are increased after a high-fat diet. Moreover, hypothalamic inflammation has been detected within 24 to 72 h of high-fat diet in mice, indicating that hypothalamic inflammation precedes the onset of obesity. High-fat diet triggers an inflammatory response in the hypothalamus of rats .
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Oct 25, 2019 · Cognitive dysfunction is linked to chronic low-grade inflammatory stress that contributes to cell-mediated immunity in creating an oxidative environment. Food is a vitally important energy source; it affects brain function and provides direct energy. Several studies have indicated that high-fat consumption causes overproduction of circulating free fatty acids and systemic inflammation. Immune ...
