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Oct 15, 2021 · Recent studies suggest that feeding a diet that is composed of a combination of high fat and high sugar content possesses a higher risk for the development of metabolic syndrome as compared to diets rich in either fat or sugar [11, 117]. Lozano and colleagues showed that 2 months of feeding of either a high-fat high fructose diet (HFHF) or HFD results in an increased body weight, leptin, and ...
- Sorabh Sharma
- 2021
These findings add to the hypothesis that a high-fat diet can alter vascular components of the brain, leading to BBB disruption and dysfunction of brain endothelial cells, but more studies are necessary to determine the direct mechanisms. A summary of plausible events following diet-induced changes in the brain vasculature is shown in Fig. 1 ...
3. Association of a High-Fat Diet with Cognitive Function 3.1. Animal Study. A previous study has demonstrated that rodents fed a diet high in saturated fatty acids (SFAs) show increased brain inflammatory markers . Increased body weight and adiposity can cause neurological perturbations.
Jan 23, 2023 · In this review, we highlight the effect of obesity and high-fat diet consumption on brain neuroinflammation and mitochondrial changes as a link between metabolic dysfunction and cognitive decline. Keywords: high-fat diets, cognitive decline, metabolic disorders, energy homeostasis, neuroinflammation, mitochondria, hippocampus, hypothalamus. 1.
Feb 3, 2021 · In animals, high-fat diet can cause endothelial dysfunction in cerebral vessels and impaired communication between neurons and vessels . These dysfunctions have been associated with cognitive impairment . Moreover, prolonged high-fat diet can induce β-amyloid depositions in rodents’ brains, contributing to AD .
- Sofia Dionysopoulou, Evangelia Charmandari, Alexandra Bargiota, Nikolaos F Vlahos, George Mastorakos...
- 2021
Dec 6, 2017 · Notably, though, while high-fat diet per se can have significant detrimental impact on cognitive processes, specific dietary components may be able to reverse these effects, omega-3 PUFA are one ...
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Oct 15, 2021 · High-fat diet (HFD) consumption is associated with cognitive deficits and neurodegenerative diseases. Since the hippocampus is extremely sensitive to pathophysiological changes, neuroinflammation and the concomitant oxidative stress induced by HFD can significantly interfere with hippocampal-dependent functions related to learning and memory.
