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- While hyperbaric oxygen treatment (HBOT) is not used to treat diabetes mellitus per se, it has been observed that when people with diabetes undergo HBOT they may experience a decrease in blood glucose levels (BGL), potentially inducing clinical hypoglycaemia. [ 1, 2] One study showed a substantial average BGL decrease of 3.5 mmol.l -1 during a 2-hour HBOT session, with no change in serum insulin concentrations, suggesting an increase in insulin sensitivity as an underlying mechanism.
www.ncbi.nlm.nih.gov/pmc/articles/PMC7819732/Assessment of insulin sensitivity during hyperbaric oxygen ...
Jun 28, 2021 · Hyperbaric oxygen therapy (HBOT) causes insulin sensitivity, but the reason for this is not known yet. The aim of the present study was to investigate the effect of HBOT on insulin sensitivity via resistin, plasminogen activator inhibitor-I (PAI -I), and adiponectin.
- Hyperbaric oxygen rapidly improves tissue-specific insulin ...
Results. HBO decreased fasting blood glucose by 19% and...
- Assessment of insulin sensitivity during hyperbaric oxygen ...
This study demonstrated significant increases in insulin...
- Hyperbaric oxygen therapy increases insulin sensitivity in ...
For patients with type 2 diabetes, we recently showed that...
- Hyperbaric oxygen rapidly improves tissue-specific insulin ...
Sep 30, 2022 · Results. HBO decreased fasting blood glucose by 19% and increased whole-body, hepatic and WAT insulin sensitivity about one-third (p <0.05 vs CON). Upon HBO, hepatic γ-ATP concentrations doubled, mitochondrial respiratory control doubled in skeletal muscle and tripled in WAT (p <0.05 vs CON).
- 10.1007/s00125-022-05797-0
- 2023
- Diabetologia. 2023; 66(1): 57-69.
This study demonstrated significant increases in insulin sensitivity during the third daily HBOT session in those with T2DM (57% increase) and without (29% increase). The increased insulin sensitivity was still measurable 30-minutes after exit from the hyperbaric chamber.
- David Wilkinson, Suzy Szekely, Brian Gue, Charmaine S Tam, Ian Chapman, Leonie K Heilbronn
- 10.28920/dhm50.3.238-243
- 2020
- Diving Hyperb Med. 2020 Sep; 50(3): 238-243.
For patients with type 2 diabetes, we recently showed that peripheral insulin sensitivity was increased during hyperbaric oxygen treatment (HBOT). This study aims to investigate whether this occurs in a non-patient population with and without type 2 diabetes, along with the mechanism of this effect.
- David Wilkinson, Mirjam Nolting, Mohd Kaisan Mahadi, Ian Chapman, Leonie Heilbronn
- 2015
- Volunteers
- Randomisation
- Experimental Protocol
- Indirect Calorimetry
- Skeletal Muscle and Wat Biopsy
- MRI and Mrs
- High-Resolution Respirometry
- Analyses of Lipid Peroxidation, Antioxidative Capacity and Oxidative Stress
- GC-MS
- Western Blotting
Fifteen male volunteers with type 2 diabetes were enrolled in this randomised, placebo-controlled, crossover clinical trial (ClinicalTrials.gov registration no. NCT04219215) but three volunteers were excluded prematurely. In total, 12 participants completed the study and data were analysed (ESM Table 1 and ESM Fig. 1). All participants were recruit...
The random allocation sequence (1:1) was generated by an experienced statistician at the German Diabetes Center (DDZ) (PB) using SAS software, version 9.3 (SAS Institute, Cary, NC, USA). Participants were randomly assigned to their treatment sequence by a person at the DDZ who was not involved in the conduct of the study. The randomisation list was...
The visits took place at an interval of 3 weeks. Each visit covered a period of 31 h, divided into four time periods (Fig. 1): basal (−24 h to −3 h); intervention (−3 h to +0 h); pre-clamp (+0 h to +2 h); and clamp (+2 h to +5 h). All participants arrived at the DDZ at 09:00 hours, after a 12 h overnight fast (−24 h to −3 h, basal period), for a 1 ...
Indirect calorimetry was performed in the canopy mode with Vmax Encore 29n (CareFusion, Höchberg, Germany) during the last 30 min of the basal, pre-clamp and clamp periods .
Skeletal muscle and WAT biopsy samples were taken from the vastus lateralis muscle and subcutaneous adipose tissue of the lower abdomen, respectively, as described before .
All MRI/MRS measurements were conducted on a 3.0-T MR scanner (Achieva X-series; Philips Healthcare, Best, the Netherlands). Intrahepatic lipid (IHL) and intramyocellular lipid (IMCL) contents were quantified by 1H-MRS. Hepatic γ-ATP and total inorganic phosphate (Pi) contents were measured with 31P-MRS using a 14 cm circular surface coil, as repor...
Ex vivo analysis of mitochondrial respiration was performed in permeabilised muscle fibres and WAT using high-resolution respirometry (Oxygraph-2k; Oroboros, Innsbruck, Austria), as previously described . Maximal mitochondrial respiration with electron input through CI and CII was determined after addition of malate (2 mmol/l), pyruvate (10 mmol/l)...
Concentrations of thiobarbituric acid reactive substances (TBARS) were assessed fluorometrically in serum and biopsy samples from subcutaneous fat and skeletal muscle according to the manufacturer’s instructions (BioTek, Bad Friedrichshall, Germany) . In skeletal muscle and WAT samples, total glutathione and oxidised glutathione (GSSG) contents wer...
Determination of atom per cent enrichment of blood [2H2]glucose was performed on a Hewlett Packard 6890 gas chromatograph equipped with a 25 m CPSil5CB capillary column (0.2 mm i. d., 0.12 μm film thickness; Chrompack/Varian, Middelburg, the Netherlands) and interfaced to a Hewlett Packard 5975 mass selective detector .
Expression levels of proteins of interest were assessed by western blot analysis, as described before . Data were normalised to housekeeping protein or total protein and expressed in arbitrary units. The following primary antibodies were purchased from Cell Signaling Technology and diluted 1:1000, unless differently specified: binding immunoglobuli...
Our results suggest that treatment with hyperbaric oxygen improves insulin sensitivity, further activating Akt protein phosphorylation to promote GLUT4 expression in T2DM, resulting in decreased blood glucose levels.
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Does hyperbaric oxygen treatment increase insulin sensitivity?
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Does hyperbaric oxygen therapy improve hyperglycaemia in humans with Type 2 diabetes?
Does HBO increase insulin sensitivity?
Does HBOT increase insulin sensitivity?
Jan 24, 2012 · This increase in insulin sensitivity is equivalent to that observed following moderate weight loss. The mechanisms underlying the insulin-sensitizing effect of hyperbaric oxygen require further elucidation.
