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  1. The stratified analysis revealed that music therapy improved memory and language ability in mild AD patients and reduced psychiatric symptoms (delusions, hallucinations, agitation/aggression, dysphoria, anxiety, euphoria, apathy, disinhibition, irritability/lability, and aberrant motor activity) and caregiver distress in moderate or severe AD patients.

    • Study Selection
    • Study Characteristics
    • Intervention Characteristics
    • Outcome Characteristics
    • Risk of Bias
    • Results of Individual Studies

    The flowchart of the study selection process is presented in Fig. 1. The literature search identified a total of 144 records. After the exclusion of duplicate records and non-relevant abstracts, 57 studies were retained. After reviewing the full text, 49 studies were excluded according to our inclusion and exclusion criteria. In the end, a total of...

    Characteristics of included studies are presented in Table 1. The final sample was composed of 8 RCTs, 4 studies were conducted in Europe (2 in France, 2 in Spain), 3 studies in Asia (2 in China, 1 in Japan), and one in the USA. All these studies were published in the English language in peer-reviewed journals. Included trials showed a total of 689...

    Music therapy approach

    Music therapy methods were heterogeneous across the included studies. In one study, the active music therapy approach used was singing with the played songs . Two other studies used the receptive (passive) music therapy approach which consists in listening to music and songs played on a CD player [31, 35]. The remaining five studies were based on a combination of both active and receptive music approaches [26, 29, 30, 34, 36].

    Comparators

    In four studies, music therapy intervention was compared to standard care [29, 30, 34,35,36], while in the four remaining studies, different interventions other than music therapy were used as comparators such as: watching nature videos , painting , cooking , and practicing meditation .

    Application of the intervention

    Only three trials were conducted by a music therapist [29, 34, 36], 1 trial was conducted by a professional choir conductor , 1 by musicians and the 3 remaining trials were conducted with facilitators with no musical expertise [26, 31, 35].

    The included studies assessed different outcomes, but we focused on domains directly related to outcome inclusion criteria: global cognition, memory, language, speed of information processing, verbal fluency, and attention. All cognitive outcomes and measurement tools used across studies are listed in Table 1.

    The quality of trials was assessed by Jadad scales . Studies with scores ≥ 3 were classified as high-quality studies and those of ≤ 2 were classified as “low-quality” studies. [26, 29,30,31, 33, 36] studies were considered high-quality studies while [34, 35] studies were considered of low-quality. Blinding of participants was not possible due to th...

    Sakamoto et al. studied the effect of music intervention (active and passive) on patients with severe dementia. Results showed that there is a short-term improvement in emotional state assessed by the facial scale which is a tool commonly used by psychologists and healthcare professionals to assess and code facial expressions, both positive and ne...

  2. May 15, 2023 · Receptive music therapy is more effective than interactive music therapy to relieve behavioral and psychological symptoms of dementia: A systematic review and meta-analysis. Journal of the American Medical Directors Association , 19(7), 568–576.

  3. Stratified analysis shows that music therapy is effective for enhancing memory and language ability in patients with mild AD and reducing the psychiatric symptoms and caregiver distress in patients with moderate or severe AD. However, no significant effect was found for activities of daily living in patients with mild, moderate, or severe AD.

    • Jihui Lyu, Jingnan Zhang, Haiyan Mu, Wenjie Li, Mei Champ, Qian Xiong, Tian Gao, Lijuan Xie, Weiye J...
    • 2018
  4. Music interventions can include music therapy but also encompass other forms of music-based interventions such as music activities, music appreciation, and music training. Therefore, music therapy is a subset of music interventions, with the former involving specialized training and a therapeutic focus, while the latter encompasses a broader scope of music-related interventions. [ 8 ]

  5. May 28, 2024 · Alzheimer’s disease (AD), the most prevalent neurodegenerative disorder, is escalating globally. Characterized by cognitive decline, emotional instability, and neuropsychiatric symptoms, AD presents a growing challenge for effective management. Current pharmaceutical treatments, primarily acetylcholinesterase inhibitors and memantine, offer symptomatic relief but fail to halt disease ...

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  7. Background The use of music interventions as a non-pharmacological therapy to improve cognitive and behavioral symptoms in Alzheimer’s disease (AD) patients has gained popularity in recent years ...

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