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Feb 10, 2015 · Introduction. Mitochondria are the major regulators of cellular energy metabolism (EM). Alterations of mitochondrial functionality have been linked to the pathogenesis of some metabolic disorders, including obesity and type II diabetes mellitus (T2DM). The principal function of mitochondria is ATP production.
- Rosa A. Busiello, Sabrina Savarese, Assunta Lombardi
- 10.3389/fphys.2015.00036
- 2015
- Front Physiol. 2015; 6: 36.
Mitochondrial uncoupling protein 1 (UCP1) is the crucial mechanistic component of heat production in classical brown fat and the newly identified beige or brite fat. Thermogenesis inevitably comes at a high energetic cost and brown fat, ultimately, is an energy-wasting organ. A constrained strategy that minimizes brown fat activity unless ...
Dec 4, 2011 · Strategies to prevent and treat obesity aim to decrease energy intake and/or increase energy expenditure. Regarding the increase of energy expenditure, two key intracellular targets may be considered (1) mitochondrial oxidative phosphorylation, the major site of ATP production, and (2) AMP-activated protein kinase (AMPK), the master regulator of cellular energy homeostasis. Experiments ...
- Susanne Klaus, Susanne Keipert, Martin Rossmeisl, Jan Kopecky
- 2012
Mar 1, 2005 · Uncoupling protein(UCP)1 is an integral membrane protein that is located in the mitochondrial inner membrane of brown adipocytes. Its physiological role is to mediate a regulated, thermogenic ...
- Stefan Krauss, Chen-Yu Zhang, Chen-Yu Zhang, Bradford B. Lowell
- 2005
Nov 11, 2000 · Body weight depends on the balance between energy intake and energy expenditure. Energy is expended on basal metabolism, exercise-induced thermogenesis, and adaptative thermogenesis, which is a response to environmental changes such as cold, excess food intake, and microbial or viral infection.
- Daniel Ricquier, Frédéric Bouillaud
- 10.1111/j.1469-7793.2000.00003.x
- 2000
- J Physiol. 2000 Nov 15; 529(Pt 1): 3-10.
These tissues utilise UCP1 and, when activated (e.g. by cold exposure), have the potential to contribute significantly to whole-body energy expenditure [7,10–12]. Notably, the occurrence of brown fat in humans correlates with leanness [7,9,13].
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May 25, 2022 · Mitochondrial I H controls cellular bioenergetics by uncoupling H + flow between the electron-transport chain and ATP synthase. I H causes thermogenesis, increases body energy expenditure and ...
