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Sep 26, 2019 · Topics. Many of you already know Harold J. Phillips (PDF, 106 KB), due to his over 20 years of work improving health outcomes for people with HIV. I am excited to welcome him to the Office of Infectious Disease and HIV/AIDS Policy (OIDP), as the Senior HIV Advisor and Chief Operating Officer of Ending the HIV Epidemic: A Plan for America.
Jul 23, 2023 · “The new guidelines we are publishing today will help countries to use powerful tools have the potential to transform the lives of millions of people living with or at risk of HIV.”At the end of 2022, 29.8 million of the 39 million people living with HIV were taking antiretroviral treatment (which means 76% of all people living with HIV) with almost three-quarters of them (71%) living with ...
Nov 27, 2023 · And among all people living with HIV, 86% know their status, 89% are accessing treatment, and 93% are virally suppressed . This represents significant progress toward attaining the new 95-95-95 global target of diagnosing 95% of HIV-positive individuals, providing ART for 95% of those diagnosed, and achieving viral suppression for 95% of those treated by 2025 [ 8 ].
Nov 30, 2021 · The researchers estimated that among adults, 79% were virally suppressed after one year of ART, 72% after two years and 65% after three years. Among children and adolescents, 64% were virally suppressed after one year of ART, 62% after two years and 59% after three years. These viral suppression rates illustrate how much farther global HIV ...
- The Evidence
- Maximizing the Effectiveness of the Prevention Strategy in Practice
- What CDC Is Doing
In 2011, the interim results of the HPTN052 clinical trial1 demonstrated a 96% reduction in HIV transmission risk among heterosexual mixed-status (also referred to as HIV-discordant) couples where the partner with HIV started antiretroviral therapy (ART) immediately versus those delaying ART initiation. The final results published in 2016 reported that there had been no HIV transmissions within these couples when the partner with HIV had a suppressed viral load (defined as having a viral load of less than 400 copies of HIV RNA per milliliter).7 Genetically linked HIV infections were observed between sexual partners in 8 couples; however, all of these transmissions occurred while the partner with HIV was not virally suppressed. In other words, linked HIV transmissions occurred only when:
•The partner with HIV had started ART but before the partner with HIV had achieved and maintained viral suppression, or
•The partner with HIV had achieved viral suppression but the ART regimen later failed or the partner with HIV had stopped taking their medication.
Three recent studies, PARTNER, Opposites Attract, and PARTNER2 (an extension of PARTNER focusing on HIV-discordant MSM couples), report similar results. None of these studies observed any genetically linked infections while the partner with HIV was virally suppressed and the couples were engaging in sex without a condom and not using pre-exposure prophylaxis (PrEP).8,9,10 In these studies, viral suppression was defined as less than 200 copies of HIV RNA per milliliter of blood; most participants with HIV in the PARTNER study had less than 50 copies of HIV RNA per milliliter of blood.8 The three studies included over 500 HIV-discordant heterosexual couples, with about half having a male partner with HIV (PARTNER), and more than 1,100 HIV-discordant MSM couples (PARTNER2; Opposites Attract) from 14 European countries, Australia, Brazil, and Thailand. Combined, these couples engaged in over 125,000 sex acts without a condom or PrEP over more than 2,600 couple-years of observation.
The studies reported transmission risk estimates and their corresponding 95% confidence intervals as:
•PARTNER study:8
The success of the TasP strategy depends on achieving and maintaining an undetectable viral load. While many people with HIV taking ART are virally suppressed, some people with HIV are currently not virally suppressed or do not maintain viral suppression over time. CDC’s national surveillance data estimate that 65% of all people with diagnosed HIV ...
CDC is working with prevention partners across the nation to prioritize efforts to maximize the impact of TasP. We will continue to strengthen longstanding programs and respond with new efforts funded through the Ending the HIV Epidemic in the U.S. initiative.17 Programmatic efforts help expand HIV testing services to people not recently tested or ...
Sep 17, 2021 · Indeed, in the UK, It has been shown that for men who have sex with men (MSM), providing immediate ART at diagnosis and assuming constant rate of condomless sex, an increase of up to 90% in the proportion of virally suppressed PLHIV within 1 year of infection is needed for a reduction in HIV incidence from 6/1000 to 1/1000 person-years . Similarly, in Australia, it has been estimated that ...
The UNAIDS 90-90-90 targets for epidemic control (i.e. that by 2020, 90% of all people living with HIV will know their status, 90% of people diagnosed with HIV infection will receive sustained antiretroviral therapy (ART), and 90% of those receiving ART will be virally suppressed) are increasingly being reached in many contexts. 1,2 However, these “three 90s” do not account for many ...
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