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Apr 1, 2022 · Use a delivery system that maximizes mucosal coverage by creating an atomized spray: Prior to the advent of nasal atomizers, nasal drug delivery efficacy was unpredictable likely due to issues of patient cooperation and runoff of the liquid straight into the throat. Atomization devices that can deliver an exact dose of fine particles have eliminated these two issues and markedly improve the ...
Jun 2, 2021 · Depending on the energy source provided in the process and the type of atomizers used there are different types of devices that can be used in drug delivery applications. Another factor that plays a major role in the efficacy of this drug delivery system is the size of the atomized particles generated.
- Anu Mohandas, Hongrong Luo, Seeram Ramakrishna
- 2021
Physicochemical drug properties, physiological barriers, delivery devices, and even head positioning may influence the efficacy of drug delivery into the brain. The advent of new nose-to- brain delivery technologies, including devices and drug formulations, and the improvement of the currently available ones may improve overall nose-to-brain delivery.
- Trevino Ja, Quispe Rc, Khan F, Novak
- 2020
- 2020
Sep 15, 2015 · Therefore, intranasally administered medications that contact the olfactory mucosa can be absorbed and delivered via the olfactory nerve pathway directly to the cerebral spinal fluid (CSF) and brain, bypassing the difficult to penetrate blood-brain barrier, even in apneic patients. 10 Therapeutic drug concentrations are rapidly attained in the CSF, oftentimes faster than with intravenous ...
- Megan Corrigan, Suprat Saely Wilson, Jeremy Hampton
- 2015
Oct 18, 2012 · In addition, due to inadequate clinical efficacy of spray pumps in patients with nasal polyps, a nasal drop formulation of fluticasone in single-dose pipettes was introduced in the EU for the treatment of nasal polyps. The rationale for this form of delivery is to improve drug deposition to the middle meatus where the polyps emerge [47, 48].
- Per Gisle Djupesland
- pgd@optinose.no
- 2013
Drug delivery as drops using a syringe or dropper. A second method of intranasal drug delivery is to take a solubilized medication (liquid form) and drip it into the nose a few drops at a time, allowing it to run down onto the nasal mucosa. This can be done using a syringe or in some instances using the packaged form of the medication to drip ...
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May 13, 2022 · An ideal atomizer can effectively deliver high doses of a drug and allow precise control of the droplet size distribution. In addition, SAW atomization applications have been proven to have a wide ...
