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In 1982, Allison first discovered the T-cell receptor. [20] Allison's research to elucidate mechanisms of T-cell responses was conducted in the 1990s at the University of California, Berkeley. [21] [22] In the early 1990s, James Allison showed that CTLA-4 acts as an inhibitory molecule to restrict T-cell responses.
Jan 27, 2023 · Allison, a Nobel laureate whose research led to the discovery of the T-cell antigen receptor and the anti CTLA-4 antibody ipilimumab, and director of James P. Allison Institute, Regental Chair of Immunology, and vice president of immunobiology at MD Anderson Cancer Center, said to The Cancer Letter. Allison is also the Olga Keith Wiess Distinguished University Chair for Cancer Research and ...
Apr 18, 2014 · James Allison, Ph.D., knows his T cells. For the past 30 years, he's studied them inside and out, learning what makes them run and hum. From his laboratory have emerged some of the most important discoveries in immunology. In the early 1980s, Allison was one of the first to identify the T cell receptor—the part of a T cell that binds to ...
Apr 18, 2014 · The Texas T Cell Mechanic. James Allison, PhD, knows his T cells. For the past 30 years, he’s studied them inside and out, learning what makes them run and hum. From his laboratory have emerged some of the most important discoveries in immunology. In the early 1980s, Allison was one of the first to identify the T cell receptor—the part of a ...
- Early Life, South Texas
- The University of Texas at Austin: Undergraduate and Graduate Training
- Scripps Clinic and Research Foundation: 1974–77
- The University of California, Berkeley: 1984–2004
- Memorial Sloan-Kettering Cancer Center: 2004–2012
- University of Texas MD Anderson Cancer Center: 2012–Present
I was born in 1948 in Alice, a small farming and oil town in the brush country of the Rio Grande Valley in South Texas. Those early years in Alice shaped who I would later become. Being in Texas, the whole town, including my two older brothers, was obsessed with football. But, I learned from a young age that being crushed under a pile of big sweaty...
I enrolled at UT Austin in the summer session immediately after high school graduation. Due to my summers in Austin, I never thought of going anywhere else. In accordance with my father’s hopes, I began as a premed student. However, I became dissatisfied with the rote memorization required in some of the pre-med courses. At the beginning of my seco...
Professors Mandy and Kitto helped me get a post-doctoral appointment in Ralph Reisfeld’s laboratory at Scripps Clinic in La Jolla, California. I felt that this was a great choice because Scripps was a hotbed of research in immunology, and because Reisfeld had recently reported the isolation and initial characterization of human histocompatibility (...
UC Berkeley is a marvelous place, teeming with bright, inventive people seeking knowledge. My time at UC Berkeley was notable for my interactions with many wonderful colleagues and students. It was a time of discovery, collegiality, long days working in the lab, and long nights partying with everyone in the lab. Max Krummel described it best by say...
I arrived in Manhattan during the summer of 2004 with most of my laboratory intact. Over the next 8 years, I did my best to help Thomas Kelly hire a cadre of the best immunologists that we could, and I feel that we succeeded in building a truly spectacular group of basic immunologists involved in a variety of studies relevant to the cancer problem....
At MSKCC, my lab had continued exploring ways in which to improve anti-tumor responses with anti-CTLA-4 treatment. We performed many experiments including combinations with chemotherapy, radiation therapy, cryoablation and with other immune checkpoint agents. After anti-CTLA-4 was shown to have some clinical success in the early clinical trials, ma...
Sep 15, 2014 · Allison then proposed that blocking CTLA-4 would enhance activation of T-cell responses against cancer, essentially taking the brake off the immune system, which it did. While most researchers investigating cancer immunology were advocating vaccines to turn “on” T cells to drive antitumor immune responses, Dr. Allison was proposing the opposite—to block the “off” signal.
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Additional proteins acting as T-cell accelerators are also required to trigger a full-blown immune response. During the 1990s, Allison studied a protein on the surface of T cells called CTLA-4. He was one of several scientists who observed that CTLA-4 functions as a brake on T cells, preventing them from attacking invaders, and thus also regulating the immune cells to avoid them attacking our ...
