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Nov 22, 2019 · A key component of the body’s oxygen-sensing system is a set of molecular hypoxia-inducible factors, or HIFs, which can respond to a need for more oxygen by turning on genes and proteins that recruit new networks of blood vessels. Cancer cells in a growing tumor can adapt to oxygen deprivation by hijacking these HIFs.
- William G. Kaelin Jr., MD
He became an independent investigator at Dana-Farber in...
- Research
These therapies treat cancer by binding to a marker on...
- Dana-Farber Staff
Uterine cancer — also known as endometrial cancer — has...
- William G. Kaelin Jr., MD
Jan 1, 2020 · A key component of the body’s oxygen-sensing system is a set of molecular hypoxia-inducible factors, or HIFs, which can respond to a need for more oxygen by turning on genes and proteins that recruit new networks of blood vessels. Cancer cells in a growing tumor can adapt to oxygen deprivation by hijacking these HIFs.
Mar 6, 2020 · The biology of hypoxic cancer cells is a product of the interplay between the prevailing oxygen tension, hypoxia-induced signalling (including that of hypoxia inducible factors (HIFs ...
- Pearl Lee, Navdeep S. Chandel, M. Celeste Simon
- 2020
Feb 17, 2023 · Here, we investigated the potential factors in the development of hypoxia in cancer, changes in signaling pathways that occur in cancer cells to adapt to hypoxic environments, the mechanisms of ...
Abstract. During the last century, it has been established that regions within solid tumors experience mild to severe oxygen deprivation, due to aberrant vascular function. These hypoxic regions are associated with altered cellular metabolism, as well as increased resistance to radiation and chemotherapy. As discussed in this Timeline, over the ...
Nov 7, 2019 · The experiments mapping the “fate” of the cells in two- and three-dimensional lab-created tissue systems and in live animals specifically showed that cells from a primary cancer exposed to low oxygen levels, or hypoxia, have a four times greater probability of becoming viable circulating tumor cells—and likely spreading to distant tissues—than those under normal oxygen conditions.
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How do cancer cells respond to oxygen deprivation?
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How do tumor cells adapt to hypoxia?
Hypoxia and dysregulated metabolism are defining features of solid tumors. How cancer cells adapt to low O2 has been illuminated by numerous studies, with “reprogrammed” metabolism being one of the most important mechanisms. This metabolic reprogramming not only promotes cancer cell plasticity, but also provides novel insights for treatment strategies. As the most studied O2 “sensor ...
