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1. • • The Polycomb repressive system plays a fundamental role in controlling gene expression during mammalian development. To achieve this, Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) bind target genes and use histone modification-dependent feedback mechanisms to form Polycomb chromatin domains and repress transcription.
     www.nature.com/articles/s41594-021-00661-y

     PRC1 drives Polycomb-mediated gene repression by ... - Nature

2. People also ask

   What is a Polycomb Repressive Complex?

   • Polycomb repressive complexes represent a paradigm of chromatin-based gene regulation in animals. The Polycomb repressive system comprises two central protein complexes, Polycomb repressive complex 1 (PRC1) and PRC2, which are essential for normal gene regulation and development.

   The molecular principles of gene regulation by Polycomb repressive co…

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7612013/

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   Which proteins assemble to form Polycomb Repressive complexes?

   • Yeast two-hybrid experiments as well as biochemical studies have revealed that the PcG proteins assemble to form two main protein complexes called Polycomb repressive complexes 1 (PRC1) and 2 (PRC2) [ 2, 3 ]. PRC1 and PRC2 are both histone-modifying machines.

   Structure and Function of the Polycomb Repressive Complexes PRC1 and

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   What is the core of Polycomb Repressive Complex 1 (PRC1)?

   • (A) The core of Polycomb repressive complex 1 (PRC1) comprises a RING1A or RING1B protein (RING1A/B) and one of six Polycomb group RING finger (PGCF) proteins (PCGF1–6).

   The molecular principles of gene regulation by Polycomb repressive co…

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   Does Polycomb Repressive Complex 2 have a mechanism of activation and drug resistance?

   • Brooun A, et al. Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance. Nat Commun. 2016;7:11384. [PMC free article] [PubMed] [Google Scholar] 38. Cao R, Zhang Y. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.

   The molecular principles of gene regulation by Polycomb repressive co…

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3. www.ncbi.nlm.nih.gov › pmc › articlesThe molecular principles of gene regulation by Polycomb...

   www.ncbi.nlm.nih.gov › pmc › articles

   Dec 1, 2021 · Polycomb repressive complexes represent a paradigm of chromatin-based gene regulation in animals. The Polycomb repressive system comprises two central protein complexes, Polycomb repressive complex 1 (PRC1) and PRC2, which are essential for normal gene regulation and development.

   • Author: Neil P. Blackledge, Robert J. Klose
   • DOI: 10.1038/s41580-021-00398-y

   • Publish Year: 2021
   • Published: 2021/12/12

4. www.nature.com › articles › s41580/021/00341-1The roles of Polycomb repressive complexes in mammalian ...

   www.nature.com › articles › s41580/021/00341-1

   Mar 15, 2021 · In this Review, we discuss the classic functions of the core Polycomb repressive complexes and introduce novel functions of the more recently identified PcG proteins.

   • Author: Andrea Piunti, Ali Shilatifard

   • Publish Year: 2021

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6. www.ncbi.nlm.nih.gov › pmc › articlesStructure and Function of the Polycomb Repressive Complexes ...

   www.ncbi.nlm.nih.gov › pmc › articles

   May 26, 2022 · Reddington et al. review the role of the Polycomb Repressive-Deubiquinase (PR-DUB) complex, which antagonizes PRC1 action. H2AK119ub is central to Polycomb-mediated gene silencing and while PRC1 attaches this histone modification, PR-DUB removes it.

7. www.ncbi.nlm.nih.gov › pmc › articlesStructure, mechanism, and regulation of polycomb-repressive ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Sep 7, 2018 · Polycomb repressive complex 2 (PRC2) methylates lysine 27 in histone H3, a modification associated with epigenetic gene silencing. This complex plays a fundamental role in regulating cellular differentiation and development, and PRC2 overexpression and mutations have been implicated in numerous cancers.

   • Author: Lindsay E. Moritz, Raymond C. Trievel
   • DOI: 10.1074/jbc.R117.800367

   • Publish Year: 2017
   • Published: 2018/09/09

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9. pubmed.ncbi.nlm.nih.gov › 33723438The roles of Polycomb repressive complexes in mammalian ...

   pubmed.ncbi.nlm.nih.gov › 33723438

   PcG proteins function on chromatin and can form two distinct complexes with different enzymatic activities: Polycomb repressive complex 1 (PRC1) is a histone ubiquitin ligase and PRC2 is a histone methyltransferase.

   • Author: Andrea Piunti, Ali Shilatifard

   • Publish Year: 2021

10. www.cell.com › plant-communications › fulltextRoles of Polycomb complexes in regulating gene expression and ...

    www.cell.com › plant-communications › fulltext

    The evolutionary conserved Polycomb Group (PcG) repressive system comprises two central protein complexes, PcG repressive complex 1 (PRC1) and PRC2. These complexes, through the incorporation of histone modifications on chromatin, have an essential role in the normal development of eukaryotes.

11. link.springer.com › article › 10Polycomb Repressive Complexes and Their Roles in Plant ...

    link.springer.com › article › 10

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    Apr 29, 2023 · Polycomb repressive complexes (PRCs) play a pivotal role in the growth and development of eukaryotes. The components of PRCs are well conserved among most eukaryotes, including humans and plants.