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Jul 25, 2006 · Dynamic instability allows microtubules to rapidly explore space. If microtubules are preferentially stabilized or destabilized when they reach certain locations, the cell can build microtubule arrays with specific shapes. For example, during mitosis, selective stabilization of microtubules that encounter chromosomes is thought to help form the ...
- Protein Power Strokes
What is a power stroke? A power stroke is large, rapid...
- Protein Power Strokes
Dynamic Instability of Microtubules. The co-existence of growing and shrinking microtubules in the same conditions is termed “dynamic instability.”. This phenomenon was first predicted based on observations of fixed in vitro reconstituted microtubules (Mitchison and Kirschner, 1984a, b).
Aug 18, 2021 · Microtubule dynamics and their control are essential for the normal function and division of all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic microtubule ...
- Nikita B Gudimchuk, Nikita B Gudimchuk, J Richard McIntosh
- 2021
Apr 19, 2018 · Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular organization, organelle trafficking and chromosome segregation. Microtubule growth and shrinkage occur via ...
- Gary J. Brouhard, Luke M. Rice
- 2018
Oct 7, 2014 · Periods of rapid microtubule polymerization alternate with periods of shrinkage in a process known as dynamic instability. In plants, dynamic instability plays a key role in determining the organization of microtubules into arrays, and these arrays vary throughout the cell cycle. In this review, we describe the mechanisms that regulate ...
- Tetsuya Horio, Takashi Murata
- 2014
Oct 20, 2020 · We present a structural mechanochemical model that explains all the phenomena of dynamic instability of microtubules, including growth, shortening, catastrophe, rescue, and pausing at both plus and minus ends. This model is based on the hypothesis that all these phenomena are driven by bent-to-straight-to-curved conformational changes of tubulins monomers and interfaces.
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Feb 10, 2023 · Microtubules are the backbone of the cytoskeleton and vital to numerous cellular processes. All the functions of microtubules are driven by dynamic instability, but its mechanism has remained unresolved for over 30 years because of conceptual difficulties inherent in the prevalent GTP-cap framework. We present a physically rigorous structural mechano-chemical model: dynamic instability is ...
