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Jul 25, 2006 · Dynamic instability allows the cell to rapidly reorganize the cytoskeleton when necessary. Dynamic microtubules are individually short-lived, so arrays of microtubules are continuously in the process of re-creation. Because microtubule growth and shrinkage are active processes, consuming energy, this turnover can be fast, on the order of minutes.
- Protein Power Strokes
What is a power stroke? A power stroke is large, rapid...
- Protein Power Strokes
Dynamic Instability of Microtubules. The co-existence of growing and shrinking microtubules in the same conditions is termed “dynamic instability.” This phenomenon was first predicted based on observations of fixed in vitro reconstituted microtubules (Mitchison and Kirschner, 1984a,b). Because reconstituted microtubules can be generated ...
Apr 19, 2018 · Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular organization, organelle trafficking and chromosome segregation. Microtubule growth and shrinkage occur via ...
- Gary J. Brouhard, Luke M. Rice
- 2018
Aug 18, 2021 · The discovery of dynamic instability 1 posed the question of how microtubules could achieve rapid changes in polymerization behaviour. The GTP cap model, formulated in the same seminal paper by ...
- Nikita B Gudimchuk, Nikita B Gudimchuk, J Richard McIntosh
- 2021
Microtubules. Microtubules, the third principal component of the cytoskeleton, are rigid hollow rods approximately 25 nm in diameter. Like actin filaments, microtubules are dynamic structures that undergo continual assembly and disassembly within the cell. They function both to determine cell shape and in a variety of cell movements, including ...
- Geoffrey M Cooper
- 2000
Sep 9, 2020 · Summary. Microtubules are cytoskeletal components involved in pivotal eukaryotic functions such as cell division, ciliogenesis, and intracellular trafficking. They assemble from αβ-tubulin heterodimers and disassemble in a process called dynamic instability, which is driven by GTP hydrolysis.
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Microtubules act as “railways” for motor-driven intracellular transport, interact with accessory proteins to assemble into larger structures such as the mitotic spindle, and provide an organizational framework to the rest of the cell. Key to these functions is the fact that microtubules are “dynamic.”. As with actin, the polymer ...
