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Mescaline or mescalin (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin.
- Pharmacological Structure
- Receptor Binding Structure
- Dosage Thresholds
- What Can You Expect?
- Potential Therapeutic Benefits
- Potential Risks
Mescaline is a substituted phenethylamine, a molecule based on the basic phenethylamine structure. Along with MDMA, 2C-B, and others, this sets it apart from the tryptamine class of psychedelics, which includes psilocybin, LSD, andDMT.
Mescaline binds to virtually all serotonin receptors in the brain but has a stronger affinity for the 1A and 2A/B/C receptors. Structurally, it is similar to LSD and is often used as a benchmark hallucinogen when comparing psychedelics. Like nearly all hallucinogens, the psychedelic effects of mescaline are likely due to its action on serotonin 2A ...
Mescaline dosage varies—albeit only slightly—according to how the compound is extracted. For instance, 100 mg mescaline hydrochloride (HCl) is approximately equivalent to 111 mg mescaline sulfate or 85 mg mescaline freebase.These are threshold doses and are given as starting points for calculating your own dosage. A more common range for mescaline ...
In whatever form it is consumed, a mescaline experience is highly hallucinogenic and lends itself to self-exploration. Many people report that it also creates a uniquely empathic effect in the user, making it useful for personal healing. Mescaline effects are generally felt within 45-90 minutes of consumption, peaking at two to four hours and lasti...
Mescaline has long been considered a powerful agent for healing and change, making it a central component of the shamanic ceremonies of many indigenous groups in the Americas. For many, a mescaline journey offers deep insight into the self and the universe, giving one a greater sense of connection and spirituality. Mescaline is also known for foste...
Due to its status as an internationally controlled substance, research into the harm potential of mescaline—especially long-term—has been limited. A lethal dose has never been identified, probably because it’s too high to be taken accidentally.In other words, to the best of our knowledge, nobody has ever died from a mescaline overdose. A 2005 study...
May 15, 2019 · Mescaline, a natural hallucinogen found in cacti, is one of the OG psychedelics. Its use has been traced back 6,000 years, to prehistoric psychonauts tripping in caves near the Rio Grande in Texas ...
- Max Daly
A definitive history of mescaline that explores its mind-altering effects across cultures, from ancient America to Western modernity. Mescaline became a popular sensation in the mid-twentieth century through Aldous Huxley’s The Doors of Perception, after which the word “psychedelic” was coined to describe it. Its story, however, extends deep into prehistory: the earliest Andean cultures
Oct 26, 2020 · Mescaline is a psychedelic alkaloid that occurs naturally in peyote, San Pedro cactus, the Peruvian torch, and other cactus varieties; these are the natural containers of mescaline that have been used in indigenous spiritual practice for thousands of years.
Jan 1, 2023 · Mescaline acts similarly to other classical psychedelics: despite its lower potency, mescaline is a 5HT2A receptor agonist, which is thought to be how it exerts its hallucinogenic effects, as do other serotonergic psychedelic substances (Table 3). Aside from binding to the 5HT2A receptor, mescaline also has activity on other receptors, including the adrenergic α1A/2A and dopaminergic D1/2/3 ...
People also ask
Is mescaline a psychedelic?
Is mescaline a psychedelic cactus?
Is mescaline a hallucinogen?
Where did mescaline come from?
How has mescaline changed psychedelic drug culture?
What is mescaline in cacti?
Oct 3, 2023 · Mescaline is one of eight natural psychedelic compounds found in certain species of cactus, particularly the peyote and san pedro cacti. Mescaline can also be found in the Peruvian torch cacti or synthesized in a lab. Much like LSD or psilocybin, it’s known for causing profound changes in sensory perception, mood, and thought patterns.
