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Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) [5] is a mitochondrial carrier protein found in brown adipose tissue (BAT). It is used to generate heat by non-shivering thermogenesis , and makes a quantitatively important contribution to countering heat loss in babies which would otherwise occur due to their high surface area-volume ratio.
Uncoupling protein 1 (UCP1) is the defining feature of brown fat and is responsible for the unique thermogenic properties of the tissue [1–3]. The protein catalyses the leak of protons across the mitochondrial inner membrane, dissipating the electrochemical proton gradient that would otherwise drive ATP production by ATP synthase.
Mitochondrial uncoupling protein 1 (UCP1) is the crucial mechanistic component of heat production in classical brown fat and the newly identified beige or brite fat. Thermogenesis inevitably comes at a high energetic cost and brown fat, ultimately, is an energy-wasting organ. A constrained strategy that minimizes brown fat activity unless ...
Uncoupling proteins, by providing a conduit for the passive flow of electrons across the inner membrane of the mitochondria, constitute a regulated source of heat production [11]. The stimulation of uncoupling protein-1 (UCP1) in brown adipose tissues represents the primary site of nonshivering thermogenesis in rodents [12].
Sep 23, 2005 · Uncoupling protein 1. UCP1 is undoubtedly an uncoupling protein and the only one that has an unchallenged thermogenic function (reviewed in more detail in Cannon & Nedergaard, 2004). Although UCP1 is mechanistically the most studied UCP family member, a consensus concerning its mode of action and the control of its functional activity has not ...
- Jan Nedergaard, Daniel Ricquier, Leslie P. Kozak
- 10.1038/sj.embor.7400532
- 2005
- EMBO Rep. 2005 Oct; 6(10): 917-921.
Mar 1, 2005 · Uncoupling protein(UCP)1 is an integral membrane protein that is located in the mitochondrial inner membrane of brown adipocytes. Its physiological role is to mediate a regulated, thermogenic ...
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Uncoupling protein 1 (UCP1) catalyses mitochondrial proton leak in brown adipose tissue to facilitate nutrient oxidation for heat production, and may combat metabolic disease if activated in humans. During the adrenergic stimulation of brown ...
