Search results
Dec 30, 2022 · This is accomplished by uncoupling the electron transport chain from the ATP synthesis. This uncoupling is a hormonally controlled process based on the presence of a mitochondrial proton channel called thermogenin. The hormone norepinephrine increases production of free fatty acids, which open the thermogenin channel.
Uncoupler. An uncoupler or uncoupling agent is a molecule that disrupts oxidative phosphorylation in prokaryotes and mitochondria or photophosphorylation in chloroplasts and cyanobacteria by dissociating the reactions of ATP synthesis from the electron transport chain. The result is that the cell or mitochondrion expends energy to generate a ...
Induction of mitochondrial uncoupling by use of synthetic or natural uncoupling agents or by activating dedicated proteins, such as UCPs or ANTs, can trigger several cellular mechanisms. The first effect, and the most well-known, is the inhibition of mitochondrial ATP production by ATP synthase due to the dissipation of the mitochondrial proton gradient.
Apart from endogenous mitochondrial uncoupling mechanisms, pharmacological mitochondrial uncoupling can be mediated by natural products and small molecules that become deprotonated when they enter the alkaline pH of the mitochondrial matrix. The mitochondrial uncoupling process is illustrated in Figure 1. 2.1 Endogenous uncoupling
Abstract. Uncouplers of oxidative phosphorylation in mitochondria inhibit the coupling between the electron transport and phosphorylation reactions and thus inhibit ATP synthesis without affecting the respiratory chain and ATP synthase (H (+)-ATPase). Miscellaneous compounds are known to be uncouplers, but weakly acidic uncouplers are ...
Furthermore, the mitochondrial uncoupling mechanism of action in cancer cells has been described in detail, with consistencies and inconsistencies between different structural classes of uncouplers. For example, many mitochondrial uncouplers decrease ATP levels and disrupt key metabolic signalling pathways such as AMPK/mTOR but have different effects on reactive oxygen species (ROS) production.
People also ask
What is an uncoupler molecule?
What are uncoupling proteins?
What are the characteristics of uncoupling agents?
What is a classical uncoupler & a pseudo-uncoupler?
Is uncoupling a secondary or a causal effect of cell death?
What is uncoupling protein (UCP)1?
Mar 1, 2005 · Uncoupling protein(UCP)1 is an integral membrane protein that is located in the mitochondrial inner membrane of brown adipocytes. Its physiological role is to mediate a regulated, thermogenic ...
