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  1. We have proposed and illustrated a framework for the planning, analysis, and reporting of data from observational studies with incomplete data. The framework places a strong emphasis on prespecifying the analysis, including how missing data will be handled subject to a priori assumptions regarding the missingness.

  2. The aim of this article is to set out an accessible framework for addressing the issues raised by missing data and illustrate its application with data from trials and observational studies. In many cases, we believe that it is unfamiliarity, rather than technical hurdles, that hinders adoption of an improved approach.

  3. Jun 1, 2021 · Despite recent reviews emphasizing the need to minimize missing data during the design stage [1], missing data remain ubiquitous in medical research.For example, in the Avon Longitudinal Study of Parents and Children (ALSPAC), a transgenerational prospective observational study of 14,500 families in the United Kingdom, only 48.2% of children completed the 12 measures collected during adolescence.

    • Katherine J Lee, Kate M Tilling, Rosie P Cornish, Roderick J A Little, Melanie L Bell, Els Goetghebe...
    • 2021
  4. Keywords: Missing data; Multiple imputation; Observational studies; Reporting; ALSPAC; STRATOS initiative 1. Background Despite recent reviews emphasizing the need to mini-mize missing data during the design stage [1], missing data remain ubiquitous in medical research. For example, in the Avon Longitudinal Study of Parents and Children (AL-

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  5. Feb 1, 2024 · There are simple methods for handling missing values, such as creating a ‘missing’ category for categorical variables, replacing missing values of a continuous variable with a summary measure (e.g. mean) of the observed values, or replacing missing values with the last observed values in longitudinal studies (also known as last observation carried forward).

  6. Missing data are ubiquitous in medical research. Although there is increasing guidance on how to handle missing data, practice is changing slowly and misapprehensions abound, particularly in observational research. Importantly, the lack of transparency around methodological decisions is threatening …

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  8. Feb 24, 2021 · Interested readers are encouraged to visit the STRATOS initiative (https://stratos-initiative.org) and in particular the missing data topic group which has recently posted a manuscript describing the ‘Treatment and Reporting of Missing Data in Observational Studies’ (TARMOS) framework (Lee et al., 2020), which gives further practical guidance on planning and reporting analyses, together ...

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