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Rearrangements fall broadly into two categories: balanced and unbalanced. A person with a balanced chromosomal rearrangement has a complete set of genetic information. However, some chromosome pieces have been moved around. Most of the time, people who have a balanced chromosomal rearrangement are perfectly healthy.
Nov 2, 2017 · A balanced chromosomal rearrangement (or balanced chromosomal abnormality, BCA) is a type of chromosomal structural variant (SV) involving chromosomal rearrangements (e.g., translocations ...
- Zirui Dong, Huilin Wang, Huilin Wang, Haixiao Chen, Hui Jiang, Jianying Yuan, Zhenjun Yang, Wen-Jing...
- 2018
In genetics, a chromosomal rearrangement is a mutation that is a type of chromosome abnormality involving a change in the structure of the native chromosome. [1] Such changes may involve several different classes of events, like deletions, duplications, inversions, and translocations. Usually, these events are caused by a breakage in the DNA ...
Jul 4, 2021 · Introduction. Complex chromosomal rearrangements (CCRs) refer to structural rearrangements which include more than two non-homologous chromosomes [].There are various classifications of CCRs based on the number of chromosomal breaks, the mode of transmission, balanced or unbalanced translocation, and the way of exchanging between three chromosomes to highly complex translocation [].
- Farzane Vafaeie, Masoume Ale Rasoul, Maryam Rahnama, Majid Mojarrad
- 10.7759/cureus.16166
- 2021
- Cureus. 2021 Jul; 13(7): e16166.
Chromosomal rearrangements might be found in more tumors as high throughput NGS sequencing becomes more widespread and affordable. Simple and Complex Rearrangements Found in Cancers. The presence of simple and balanced rearrangements (summarized in Table 2) can increase cancer risk. Simple rearrangements have no or limited alterations at the ...
Nov 16, 2011 · Genomic rearrangements can result in losses, amplifications, translocations and inversions of DNA fragments thereby modifying genome architecture, and potentially having clinical consequences.
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What is a chromosomal rearrangement?
What is a balanced chromosomal rearrangement?
What is a balanced chromosomal rearrangement (BCA)?
What happens if a chromosome rearrangement is unbalanced?
Are chromosomes balanced or unbalanced?
What are complex chromosome rearrangements (CCRs)?
Chromosome rearrangements can be classified as deletions, duplications, insertions, inversions, and translocations. These events are caused by a break in long stretches of DNA involving at least two different locations, followed by a re-ligation of the broken ends to produce a new chromosomal arrangement [24].
