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  1. The differential diagnosis of Fever of Unknown Origin (FUO) is very extensive, and includes infectious diseases (ID), neoplasms and noninfectious inflammatory diseases (NIID). Many FUO remain undiagnosed.

  2. Proposed algorithm for an approach to fever of unknown origin (FUO). CT indicates computed tomography; DVT, deep vein thrombosis; IE, infective endocarditis; LMWH, low-molecular-weight heparin; TA, temporal artery; and Tc, technetium. See for minimal diagnostic workup to qualify as FUO.

    • Ophyr Mourad, Valerie Palda, Allan S. Detsky
    • 2003
  3. Aug 23, 2021 · What constitutes an initial investigation or appropriate initial standard approach prior to rendering the diagnosis of fever of unknown origin is currently based on case series and expert opinion.

    • William F. Wright, Catharina M. Mulders-Manders, Paul G. Auwaerter, Chantal P. Bleeker-Rovers
    • 2021
  4. Feb 2, 2022 · Suggested Diagnostic and Management Algorithm for Fever of Unknown Origin (FUO). The approach should be individualized on the basis of the specific clinical scenario.

  5. Jun 10, 2024 · Consensus was reached on 5 themes: (1) incorporating epidemiologic factors, such as geographic location and travel history; (2) updated criteria for classifying FUO or IUO; (3) initial evaluation approaches; (4) a classification system for diagnoses; and (5) recommendations for judicious limitation of empiric therapies.

  6. Aug 14, 2023 · There is no clear-cut diagnostic approach to fever of unknown origin (FUO). Thorough history with a focus on the most probable etiology based on the patient’s symptoms is the key to pinpoint the origin of FUO.

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  8. Nov 28, 2023 · The definitions and special populations with FUO, as well as the diagnostic approach to the adult with FUO, are reviewed here. Specific discussions of the common and uncommon entities causing FUO and the approach to children with FUO are presented separately.