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Dec 24, 2017 · Blood culture (BC) remains the reference standard for the diagnosis of bloodstream infections (BSIs), but contaminations represent up to 50% of positive BCs .A contaminant is defined as a microorganism that is supposed to be introduced into the culture during either specimen collection or processing and that is not pathogenic for the patient.
- S. Dargère, H. Cormier, R. Verdon
- 2018
Since a major consequence of contaminated cultures is a lower positive predictive value (PPV) for the blood culture test, and the pretest probability of bacteremia is a key determinant of PPV , there have been increasing endeavors to discourage the utilization of blood cultures in patients at very low risk for this disease. For example, clinical bacteremia prediction rules have been developed ...
the monitoring and reporting of blood culture contamination rates is a laboratory quality best practice. 4. Because blood is a normally sterile body site, positive blood cultures with a known pathogen have a generally overall high positive predictive value for infection. However, blood culture contamination is a significant problem.
- The Case
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A 62-year-old man with type 2 diabetes mellitus, chronic kidney disease, and a history of ventricular tachycardia with an automated implantable cardiac defibrillator (AICD) came to his primary care physician (PCP) with symptoms of shaking, weakness, and vomiting. He denied fevers. The physical examination was unremarkable except for the presence of...
The case history that forms the basis for this commentary illustrates several of the important complexities and inefficiencies of modern medicine, some of which resulted in medical errors. These include: 1. A patient with multiple underlying medical problems that predispose to infection; 2. Isolation of a microorganism from blood cultures that in m...
1. Richter SS, Beekmann SE, Croco JL, et al. Minimizing the workup of blood culture contaminants: implementation and evaluation of a laboratory-based algorithm. J Clin Microbiol. 2002;40:2437-2444. [go to PubMed] 2. Weinstein MP, Towns ML, Quartey SM, et al. The clinical significance of positive blood cultures in the 1990s: a prospective comprehens...
Table. Microorganisms Isolated from Blood Categorized According to Clinical Significance. (Adapted with permission. Original table © 1997 by the University of Chicago. [Weinstein MP, Towns ML, Quartey SM, et al. The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiolog...
Figure. Patterns of positivity in sequential blood cultures as an aid to the differentiation of clinically important infection versus contamination. (Reprinted with permission. Figure© 1983 by the University of Chicago. [Weinstein MP, Reller LB, Murphy JR, Lichtenstein KA. The clinical significance of positive blood cultures: a comprehensive analys...
Sep 10, 2024 · Laboratory analysis of blood cultures is vital to the accurate and timely diagnosis of bloodstream infections. However, the reliability of your testing depends on clinical compliance with collection procedures that limit the risk of inconclusive or incorrect results. False negative blood culture results due to inadequate volumes of blood can:
5. Collect the frst blood culture set, usually consisting of one aerobic and one anaerobic bottle. 6. Collect 10 mL of blood in each bottle for a target total blood volume of 20 mL in each set (40 mL when collecting two blood culture sets). • The volume of blood collected, not timing, is most critical.
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Contents: This review describes the burden of BCC and analyses the main current issues and controversies in interpreting the occurrence of potential BC contaminants. It focuses on the best-described approaches to decide whether BCC is present and discusses the different strategies of prevention in adults. Implications: Each institution should ...
