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  1. Oct 4, 2024 · The attributable fraction is a standard concept of epidemiology. The population attributable fraction (PAF) is a useful measure as it quantifies the fraction of disease burden (for example years of life lost) attributable to a specific risk factor in a population in a way which is understandable and easy to communicate.

  2. The population attributable fraction is the proportional reduction in population disease or mortality would occur if exposure to a risk factor were reduced to an alternative ideal exposure scenario. The number of deaths and DALYs attributed to a risk factor is quantified by applying the population attributable fraction to the total nubmer of deaths or the total burden of disease.

  3. In the case of smoking it is necessary to first estimate the burden due to the relevant health outcomes. So, first the population level burden of disease estimates for e.g. lung cancer need to be quantified. This number is then multiplied by the PAF which represents a percental share of disease burden attributable to a certain risk factor.

  4. The potential impact fraction (PIF) is another measure that is calculated based on both the prevalence of a risk factor and the associated relative risk. The PAF is a special case of the PIF. PIF Is a reduction in the fraction of a disease that results from a proportional change in disease incidence when exposure to a risk factor is changed .

  5. For risks that do not produce a SEV as part of their modeling process, the population attributable fraction (PAF, i.e., the proportion of a disease that is estimated to be attributed to the risk factor given its exposure in a population and the relative risk of the outcome between those exposed and those exposed at the theoretical minimum risk ...

  6. Jun 13, 2019 · Population attributable fraction (PAF) is widely used to measure the disease burden attributable to a given risk factor. Concerns on improper estimation of PAF in ecological studies are raised in consideration of potential ecological bias. However, if unbiased relative risks (RR) are available, estimation of PAF from ecological studies is ...

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  8. Now, a powerful risk factor to which only a small proportion of the population is exposed may generate a lower disease burden than a weaker risk factor to which a large proportion of the population is exposed . It is precisely that kind of information, beyond RRs, that decision-makers in public health are asking for: quantitative tools designed to rank problems based on disease burden or ...

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