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Nov 8, 2023 · Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. Based on large-scale DNA sequencing of human tumours, the most frequent type of complex chromosome ...
- Characterising chromosome rearrangements: recent technical ...
Thus, complex chromosome rearrangements, involving more than...
- Characterising chromosome rearrangements: recent technical ...
Nov 16, 2011 · Thus, complex chromosome rearrangements, involving more than two chromosomes, can be deciphered (Fauth et al., 2006), and in some instances other inter-chromosomal aberrations may be identified ...
- S Le Scouarnec, S M Gribble
- 2012
Abstract. Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. The most frequent type based on large-scale DNA sequencing of human tumors is chromothripsis, a massive, localized and clustered rearrangement of one (or a few) chromosomes seemingly acquired in a single event.
Complex Chromosome Rearrangement. Complex chromosome rearrangements have three or more breakpoints and may lead to a balanced or an unbalanced copy-number state [60,61]. Recent NGS breakpoint studies have paved the way to understanding the mutational mechanisms and defining the genomic structure of these rearrangements.
(a) Complex rearrangements of the short arm of human chromosome 17 revealed by FISH analysis (adapted, with permission, from Ref. ). (b) Complex rearrangement at 1q revealed by BAC aCGH. A BAC array is shown on the left with the chromosome numbers depicted above.
- Feng Zhang, Claudia M.B. Carvalho, James R. Lupski, James R. Lupski
- 10.1016/j.tig.2009.05.005
- 2009
- 2009/07
Complex chromosome rearrangement. Complex chromosome rearrangements have three or more breakpoints and may lead to a balanced or an unbalanced copy-number state [60,61]. Recent NGS breakpoint studies have paved the way to understanding the mutational mechanisms and defining the genomic structure of these rearrangements.
Complex genomic rearrangements have been reported in lymphoma. 40-45 Complex chromosomal translocations leading to gene fusions are also found in solid cancers, 19 including whole arm translocations and isochromosomes in head and neck squamous cell carcinoma, 46 complex genomic rearrangements including inversions in pancreatic cancer, 47 and rearrangements including tandem duplications in ...
