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What is systems biology?
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Systems biology is the computational and mathematical analysis and modeling of complex biological systems. It is a biology -based interdisciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach ( holism instead of the more traditional reductionism ) to biological research.
- ISB’s Innovation Engine
- Cross-Disciplinary Teams
- Network of Networks
- Multiscale Modeling
- Single Cell Analysis
- Understanding Proteomics
A fundamental tenet of systems biology is that solving challenging biological problems always requires the development of new technologies in order to explore new dimensions of data space. New data types require novel analytical tools. This virtuous cycle of biology driving technology driving computation can exist only in a cross-disciplinary envir...
In describing systems biology and the distinguishing characteristics of ISB’s approach, we always emphasize how our lab groups are intentionally and necessarily cross-disciplinary. One of our labs, for example, includes molecular biologists, microbiologists, geneticists, engineers, oceanographers, and even an astrophysicist. The complexity of biolo...
With networks, we can organize and integrate information at different levels. Social networks have transformed communications in the 21st Century, democratizing our platforms for communications. At ISB we are also concerned with networks. One of the tenets of systems biology we often refer to is the “Network of Networks.” On a biological level, our...
Whether we explicitly recognize it or not, multiscale phenomena are part of our daily lives. We organize our time in days, months and years, as a result of the multiscale dynamics of the solar system. Our society is organized in a hierarchical structure, from towns to states, countries and continents. The human body is a complex machine, with many ...
It is well known that there is no “average” patient. Therefore, in clinical trials encompassing large groups of patients, one needs to consider the characteristics of each patient, including each person’s individual genetic propensity to respond to a drug in a particular way. The statistical analysis of population averages suppresses valuable indiv...
If DNA is the blueprint for life, then proteins are the bricks. The genes in DNA are translated into proteins, strings of amino acids that fold into three-dimensional structures. The type and order of the amino acids in a protein will change its shape and determine its special function. Proteins are the molecules that make life happen: they are the...
systems biology, the study of the interactions and behaviour of the components of biological entities, including molecules, cells, organs, and organisms. The organization and integration of biological systems has long been of interest to scientists.
- David Galas
May 2, 2022 · Systems biology is an approach in biomedical research to understanding the larger picture—be it at the level of the organism, tissue, or cell—by putting its pieces together. It’s in stark contrast to decades of reductionist biology, which involves taking the pieces apart.
Systems biology is an experimental science, and many definitions of systems biology include repeated iterations between modeling, prediction and experimentation at their core. However, this seems unsatisfactory if the prediction remains restricted to “local” perturbations of existing systems.
In order to explain why organisms exist and how they relate to cells, we can draw analogies between biology and the state-citizen model. Both systems introduce a hierarchy of needs which subordinates the latter to the former. In a biological system subordination applies to cells, while in a state it affects individuals.
What is the concept of systems biology of the cell — what are its roots, what are its aims, and (in a minor way) what are the technological assets it depends on? (Figure 1).
