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In this review, we aim to provide a comprehensive view of the complex role that platelets play in hemostasis and thrombosis, and to discuss the major clinical implications of these fundamental blood components, with a focus on hemostatic platelet-related disorders and existing and emerging antithrombotic therapies.
- Platelets in hemostasis and thrombosis: Novel mechanisms of ...
Furthermore, whilst platelets play a pivotal role in...
- Mechanism Action of Platelets and Crucial Blood Coagulation ...
However, platelets are the smallest blood component produced...
- Platelets in hemostasis and thrombosis: Novel mechanisms of ...
Furthermore, whilst platelets play a pivotal role in hemostasis and thrombosis, they are also versatile cells and are involved in multiple functions, including inflammation, immune responses, lymphatic vessel development, angiogenesis, tumor metastasis, as well as atherosclerosis [106-109]. Further elucidations of platelet versatilities will provide insights into development of new methods to ...
However, platelets are the smallest blood component produced from the very large bone marrow cells called megakaryocytes and they play a fundamental role in thrombosis and hemostasis. Platelets contribute their hemostatic capacity via adhesion, activation and aggregation, which are triggered upon tissue injury, and these actions stimulate the coagulation factors and other mediators to achieve ...
Jan 18, 2024 · Increasing evidence supports an important role for platelets in venous thrombosis through various mechanisms. 133,134 Cross talk between platelets and monocytes seems to be important in the initiation and propagation of venous thromboembolism, partly mediated by induction of tissue factor expression on the surface of monocytes following platelet binding. 135,136 Platelet-dependent generation ...
Oct 23, 2022 · In this review, we provide a comprehensive view of the complex role that platelets play in hemostasis and thrombosis, and we discuss the major clinical implications of these fundamental blood ...
- Alina Scridon
Oct 23, 2022 · Hemostasis is a physiological process critical for survival. Meanwhile, thrombosis is amongst the leading causes of death worldwide, making antithrombotic therapy one of the most crucial aspects of modern medicine. Although antithrombotic therapy has progressed tremendously over the years, it remains far from ideal, and this is mainly due to the incomplete understanding of the exceptionally ...
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Jan 19, 2018 · Platelets, non-nucleated blood components first described over 130 years ago, are recognized as the primary cell regulating hemostasis and thrombosis. The vascular importance of platelets has been attributed to their essential role in thrombosis, mediating myocardial infarction, stroke, and venous thromboembolism. Increasing knowledge on the platelets’ role in the vasculature has led to many ...
