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- The osteoclasts precursor cells are recruited to the bone surface where they fuse to form multinucleated cells.
www.sciencedirect.com/science/article/pii/B9780123820402100012
Novak S, Roeder E, Kalinowski J, et al. Osteoclasts derive predominantly from bone marrow-resident CX(3)CR1(+) precursor cells in homeostasis, whereas circulating CX(3)CR1(+) cells contribute to osteoclast development during fracture repair.
- Histology, Osteoclasts - StatPearls - NCBI Bookshelf
Osteoclast progenitors fuse together on the bone surfaces...
- Osteoclasts: What Do They Do and How Do They Do It?
The osteoclast, which is the sole bone-resorbing cell, is a...
- Histology, Osteoclasts - StatPearls - NCBI Bookshelf
Apr 24, 2023 · Osteoclast progenitors fuse together on the bone surfaces but are primarily found in bone marrow, where they derive from macrophage/dendritic cell precursors, which arise from myeloid progenitor cells, which ultimately originate from hematopoietic stem cells.
- Irfan A. Khan, Bruno Bordoni
- 2023/04/24
Feb 1, 2024 · Through these mechanisms, osteoclasts signal osteoblast precursors to prepare for bone formation. A functional imbalance in osteoclasts and osteoblasts unbalances coupling, causing abnormal...
The osteoclast, which is the sole bone-resorbing cell, is a unique polykaryon whose activity, in the context of the osteoblast, dictates skeletal mass. All forms of acquired osteoporosis reflect increased osteoclast function relative to that of the osteoblast.
In the transition phase, mature, bone resorptive osteoclasts promote switching toward bone formation in three ways: by releasing coupling factors from the matrix, by directly secreting them, and by engaging in direct cell–cell contact with cells of the osteoblast lineage.
Mar 29, 2013 · Osteoclasts, the bone-resorbing cells, play a pivotal role in skeletal development and adult bone remodeling. They also participate in the pathogenesis of various bone disorders.
Jan 1, 2012 · The osteoclasts precursor cells are recruited to the bone surface where they fuse to form multinucleated cells. The second factor is osteoblasts; it is the cells that form bone, characterized by their unique ability to secrete a type I collagen-rich ECM that eventually mineralizes.
