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  1. U.S. Route 50 (US 50) runs east–west across the southern part of the state of Ohio, passing through Cincinnati, Chillicothe, and Athens. It is mainly a two-lane road except for the easternmost and westernmost parts. Near Athens it runs concurrently with State Route 32 (SR 32), a four-lane divided highway known as Corridor D, and from ...

  2. Nov 4, 2022 · U.S. Route 50 is a 3,200-mile road that spans 11 states and showcases some of America’s most beautiful scenery -- especially in Ohio. This route winds its way through the entire southern portion of Ohio, showing off some of the Buckeye State's best rural scenery and most charming small towns. The roughly 200-mile stretch of Route 50 through ...

  3. U.S. Route 50. U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80) in West Sacramento, California, to Maryland Route 528 (MD 528) in Ocean City, Maryland, on the Atlantic Ocean. Until 1972, when it was replaced by Interstate Highways west ...

  4. US 50 is Main Street through town, a quaint small town with many old buildings. Paint Creek runs west of town. Chillicothe was the first and third Capital of Ohio. Tecumseha, named after the great Shawnee Chief, is now a most enduring and extravagant outdoor drama, presented to thousands of visitors nightly in the summer at the beautiful ...

  5. Aug 4, 2021 · Written by. April Dray. Most people don't realize "The Loneliest Road In America" passes right through Ohio. Stretching across 11 states and showcasing some of America's best scenery, US Route 50 is a 3,200-mile road everyone in America has likely traveled at least once. It winds its way through the southern portion of Ohio, showing off some of ...

  6. After bisecting Missouri from Kansas City to St. Louis, US-50 crosses the Mississippi River into a much older and more settled landscape, through the agricultural heartlands of Illinois, Indiana, and Ohio. After climbing into the Appalachian backwoods of West Virginia, US-50 emerges suddenly into the wealth and power of downtown Washington DC ...

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  8. Jul 29, 2017 · Route 50 in Ohio. Route 50 enters eastern Ohio from Parkersburg, West Virginia, by crossing the Ohio River. After 200 miles of rolling countryside and small towns, it reaches the Ohio River again at Cincinnati, where the river forms the border with Kentucky. It then follows the river west to Indiana. Living on Route 50 in eastern Ohio.

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