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Feb 6, 2020 · Because the structural variants from a given cancer are often highly clustered, we grouped rearrangements into clusters on the basis of the proximity of breakpoints, the overall number of events ...
- Yilong Li, Nicola D Roberts, Jeremiah A Wala, Jeremiah A Wala, Ofer Shapira, Ofer Shapira, Steven E ...
- 2020
Jan 29, 2024 · Rearrangements were first linked to oncogenesis with the identification of the BCR–ABL1 gene fusion in leukemia 123 and have since been implicated in the development of a number of cancer types ...
Feb 5, 2020 · Two cluster groups were produced: tier 1, pairs of reciprocal clusters with both clusters that had P < 0.1, and tier 2, pairs of reciprocal clusters with only one of both clusters having P < 0.1.
- Bernardo Rodriguez-Martin, Bernardo Rodriguez-Martin, Eva G. Alvarez, Eva G. Alvarez, Adrian Baez-Or...
- 2020
Such rearrangements have the potential to cause cancer if they mutate a tumor suppressor gene or activate an oncogene 2 and can also contribute to tumor heterogeneity and clonal evolution as mechanisms for metastasis and drug resistance. 3, 4 Thus, chromosomal rearrangements are important in cancer etiology. This review will first describe recent advancements in technologies that drove the ...
Abstract. Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. Based on large-scale DNA sequencing of human tumours, the most frequent type of complex chromosome rearrangement is chromothripsis, a massive, localized and clustered rearrangement of one (or a few) chromosomes seemingly acquired in a single event.
Sep 25, 2018 · Complex clusters of rearrangements are a challenge in interpretation of cancer genomes. Some clusters of rearrangements demarcate clear amplifications of driver oncogenes but others are less well understood. A detailed analysis of rearrangements within these complex clusters could reveal new insights into selection and underlying mutational ...
People also ask
Why are cancer rearrangements grouped into clusters?
What is the role of rearrangement in cancer?
Do rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors?
Which alterations occur more often than other alterations in tumor cells?
How are chromosomal structures rearranged?
A range of technological advances has improved our ability to detect and understand these rearrangements leading to speculation of causal mechanisms including defective DNA double strand break (DSB) repair and faulty DNA replication. A better understanding of these potential cancer-causing mechanisms will lead to novel therapeutic regimes to ...
