Search results
Jan 27, 2023 · He didn’t even think there was such a thing as T cells, because he was an antibody guy, through and through. He just thought it was some kind of weird macrophage that picked up an antibody molecule.” Allison was not convinced. He wanted to understand how these cells worked. “At the time, the T cell receptor hadn’t been discovered.
Apr 18, 2014 · James Allison, Ph.D., knows his T cells. For the past 30 years, he's studied them inside and out, learning what makes them run and hum. From his laboratory have emerged some of the most important discoveries in immunology. In the early 1980s, Allison was one of the first to identify the T cell receptor—the part of a T cell that binds to ...
Oct 22, 2018 · There was always more to learn—and besides, Allison wasn’t totally convinced that Linsley et al. had really solved the T-cell activation mystery. “I knew there were two ways you can get ...
Apr 18, 2014 · The Texas T Cell Mechanic. James Allison, PhD, knows his T cells. For the past 30 years, he’s studied them inside and out, learning what makes them run and hum. From his laboratory have emerged some of the most important discoveries in immunology. In the early 1980s, Allison was one of the first to identify the T cell receptor—the part of a ...
- Early Life, South Texas
- The University of Texas at Austin: Undergraduate and Graduate Training
- Scripps Clinic and Research Foundation: 1974–77
- The University of California, Berkeley: 1984–2004
- Memorial Sloan-Kettering Cancer Center: 2004–2012
- University of Texas MD Anderson Cancer Center: 2012–Present
I was born in 1948 in Alice, a small farming and oil town in the brush country of the Rio Grande Valley in South Texas. Those early years in Alice shaped who I would later become. Being in Texas, the whole town, including my two older brothers, was obsessed with football. But, I learned from a young age that being crushed under a pile of big sweaty...
I enrolled at UT Austin in the summer session immediately after high school graduation. Due to my summers in Austin, I never thought of going anywhere else. In accordance with my father’s hopes, I began as a premed student. However, I became dissatisfied with the rote memorization required in some of the pre-med courses. At the beginning of my seco...
Professors Mandy and Kitto helped me get a post-doctoral appointment in Ralph Reisfeld’s laboratory at Scripps Clinic in La Jolla, California. I felt that this was a great choice because Scripps was a hotbed of research in immunology, and because Reisfeld had recently reported the isolation and initial characterization of human histocompatibility (...
UC Berkeley is a marvelous place, teeming with bright, inventive people seeking knowledge. My time at UC Berkeley was notable for my interactions with many wonderful colleagues and students. It was a time of discovery, collegiality, long days working in the lab, and long nights partying with everyone in the lab. Max Krummel described it best by say...
I arrived in Manhattan during the summer of 2004 with most of my laboratory intact. Over the next 8 years, I did my best to help Thomas Kelly hire a cadre of the best immunologists that we could, and I feel that we succeeded in building a truly spectacular group of basic immunologists involved in a variety of studies relevant to the cancer problem....
At MSKCC, my lab had continued exploring ways in which to improve anti-tumor responses with anti-CTLA-4 treatment. We performed many experiments including combinations with chemotherapy, radiation therapy, cryoablation and with other immune checkpoint agents. After anti-CTLA-4 was shown to have some clinical success in the early clinical trials, ma...
Oct 1, 2018 · And at the heart of this revolution is a tiny but extremely powerful immune cell called a T cell. The mighty T cell. T cells live in our bodies and protect us from foreign invaders, such as bacteria and viruses. And, under the right conditions, they can also destroy cancer cells. T cells circulate our bodies scanning for molecular flags that ...
People also ask
Why did Allison not think there was a T cell?
Why did Allison win the Nobel Prize?
Who was Jim Allison?
Can T cells recognize cancer?
Did you know the T cell receptor was not discovered?
Could a T-cell killing machine be a Nobel Prize winner?
Taking the brake off T cells. The Nobel Prize recognizes Allison’s breakthrough work with T cells, the “soldiers” of the immune system that battle invaders and abnormal cells like cancer, bacteria and viruses. While T cells are fierce opponents of disease, they don’t attack every invader that comes along.
