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Nov 22, 2019 · A key component of the body’s oxygen-sensing system is a set of molecular hypoxia-inducible factors, or HIFs, which can respond to a need for more oxygen by turning on genes and proteins that recruit new networks of blood vessels. Cancer cells in a growing tumor can adapt to oxygen deprivation by hijacking these HIFs.
- William G. Kaelin Jr., MD
He became an independent investigator at Dana-Farber in...
- Research
In trial after clinical trial, metastatic colorectal cancer...
- Dana-Farber Staff
Uterine cancer — also known as endometrial cancer — has...
- William G. Kaelin Jr., MD
Nov 28, 2014 · 28 Nov 2014. Cancer requires a blood supply to deliver the nutrients and oxygen it needs to grow and survive. It had been thought that tumours create the blood supply they need by stimulating the formation of new blood vessels, a process called angiogenesis. But this no longer appears to be the only process going on.
Jan 1, 2020 · A key component of the body’s oxygen-sensing system is a set of molecular hypoxia-inducible factors, or HIFs, which can respond to a need for more oxygen by turning on genes and proteins that recruit new networks of blood vessels. Cancer cells in a growing tumor can adapt to oxygen deprivation by hijacking these HIFs.
Also, vascular density tends to decrease as tumours grow, leading to zones of ischaemia and ultimately necrosis as tumours ‘outgrow their blood supply’ (Peterson, 1991). Finally, tumour blood vessels are structurally abnormal. On the basis of their anatomic and functional properties, we have recently classified tumour blood vessels into at ...
Mar 3, 2023 · Cancer cells grow fast. This often causes tumours to outgrow the reach of their surrounding vascular system. This results in decreased oxygen availability, called hypoxia. ‘This lack of oxygen triggers several processes that promote metastasis,’ explains Liu. ‘It activates genes that promote the motility of tumour cells, and it makes it ...
May 19, 2020 · Cancer cells often are starved of oxygen — a condition called hypoxia. One instance where this might occur is when enlarging tumors outgrow the network of blood vessels that supplies tumor cells ...
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Sep 23, 2016 · Solid tumours, in particular, develop oxygen- and nutrient-deprived microenvironments as cancer cells outgrow O 2 supply via native blood vessels and trigger aberrant angiogenic signalling that ...
