Search results
Intracellular supply of protons is replenished
quizlet.com
- The result is that the cell or mitochondrion expends energy to generate a proton-motive force, but the proton-motive force is dissipated before the ATP synthase can recapture this energy and use it to make ATP. Because the intracellular supply of protons is replenished, uncouplers actually stimulate cellular metabolism.
en.wikipedia.org/wiki/Uncoupler
People also ask
Why do uncouplers stimulate cellular metabolism?
How do uncouplers affect protein secretion?
How do mitochondrial uncouplers affect cell signaling?
Do mitochondrial uncouplers elicit different cellular responses?
What is systemic effect of mitochondrial uncouplers?
Because the intracellular supply of protons is replenished, uncouplers actually stimulate cellular metabolism. Uncouplers are capable of transporting protons through mitochondrial and lipid membranes.
Mitochondrial uncouplers increase mitochondrial respiration. Mitochondrial uncouplers mediate proton (H +) transport into the mitochondrial matrix via a pathway independent of ATP synthase [9,10]. Uncouplers bind to protons in the intermembrane space proceeding to cross the inner mitochondrial membrane (IMM).
Moving forward, small-molecule mitochondrial uncouplers represent an alternative strategy to non-genomically increase cellular energy expenditure and improve metabolic syndrome.
Jul 30, 2019 · For instance, a severe mitochondrial uncoupling can lead to rapid cellular ATP depletion and, if the stress persists, to the triggering of other cellular mechanisms, such as cell death. In this part of the review, we will cover how cells can respond to mitochondrial uncoupling.
- Stéphane Demine, Patricia Renard, Thierry Arnould
- 2019
May 25, 2022 · All of the chemical uncouplers examined in this work have two mechanisms of action, a protonophoric activity affecting all cell membranes and an IMM-specific H + leak through AAC and UCP1.
Feb 10, 2015 · Mitochondria are the major regulators of cellular energy metabolism (EM). Alterations of mitochondrial functionality have been linked to the pathogenesis of some metabolic disorders, including obesity and type II diabetes mellitus (T2DM).
Jul 30, 2019 · Induction of mitochondrial uncoupling by use of synthetic or natural uncoupling agents or by activating dedicated proteins, such as UCPs or ANTs, can trigger several cellular mechanisms.
