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  1. Aug 3, 2023 · One of the most commonly used bioinformatics tools today to study DNA and protein sequences is called BLAST. BLAST stands for Basic Local Alignment Search Tool. It is a widely used bioinformatics program that was first introduced by Stephen Altschul et al. in 1990 and has since become one of the most popular tools for sequence similarity search.

    • Databases

      Example. A few popular databases are GenBank from NCBI...

  2. BLAST (biotechnology) In bioinformatics, BLAST (basic local alignment search tool) [3] is an algorithm and program for comparing primary biological sequence information, such as the amino-acid sequences of proteins or the nucleotides of DNA and/or RNA sequences.

  3. Jul 1, 2004 · The LinkOut icons on the BLAST report provide a shortcut to collections of related information, which can be a powerful tool in itself. For example, when a protein–protein comparison of the E.coli mismatch repair protein found earlier (GenPept accession number AAM82372) is performed against nr but limited to Mus musculus , some very strong hits have uninformative definition lines (Figure ...

    • Scott D. McGinnis, Thomas L. Madden
    • 10.1093/nar/gkh435
    • 2004
    • 2004/07/07
  4. In this video, we'll walk you through everything you need to know about BLAST—one of the most essential tools in bioinformatics.📖 What You'll Learn:What is ...

    • 8 min
    • 76
    • Bioinfonetix
  5. 1. Introduction. BLAST is an acronym for Basic Local Alignment Search Tool and refers to a suite of programs used to generate alignments between a nucleotide or protein sequence, referred to as a “query” and nucleotide or protein sequences within a database, referred to as “subject” sequences. The original BLAST program used a protein ...

    • David Wheeler, Medha Bhagwat
    • 2007
  6. Aug 6, 2024 · The Basic Local Alignment Search Tool (BLAST) finds regions of similarity between sequences. The program compares nucleotide or protein sequences and calculates the statistical significance of matches. BLAST can be used to infer functional and evolutionary relationships between sequences as well as help identify members of gene families.

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  8. Feb 10, 2001 · Abstract. Searching for similarities between biological sequences is the principal means by which bioinformatics contributes to our understanding of biology. Of the various informatics tools developed to accomplish this task, the most widely used is BLAST, the basic local alignment search tool. This article discusses the principles, workings ...

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